In vitro study of functional parameters and cardiac arrhythmia in localized ischemia followed by reperfusion in two rat strains (Sprague Dawley and Wistar)
Javouhey, A.; Rochette, L.; Rocquelin, G.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 183(6): 530-536
1989
ISSN/ISBN: 0037-9026 PMID: 2534957 Document Number: 342844
The cardiac parameters of two rat strains [Wistar (W) and Sprague Dawley (SD)] were compared during Langendorff perfusion. The values of coronary flow, heart rate, amplitude of contraction and the incidence of arrhythmias were studied during three 10 minutes periods: perfusion, ischemia by coronary artery occlusion and reperfusion. The values of heart rate and coronary flow of SD hearts are always higher than those of W hearts whatever the potassium (K+) concentration of perfusate (5.9 or 3 mM). Furthermore, with a high K+ perfusate (5.9 mM) and during ischemia. W rat hearts showed ventricular tachycardia periods which are never observed in SD rat hearts. It is concluded that W rat hearts present a higher sensitivity to the development of dysfunction than SD rat hearts.