Cyclosporine augments renal mitochondrial function in vivo and reduces renal blood flow
Lemmi, C.A.; Pelikan, P.C.; Sikka, S.C.; Hirschberg, R.; Geesaman, B.; Miller, R.L.; Park, K.S.; Liu, S.C.; Koyle, M.; Rajfer, J.
American Journal of Physiology 257(5 Pt 2): F837-F841
1989
ISSN/ISBN: 0002-9513 PMID: 2589485 Document Number: 342770
The in vivo action of cyclosporine A (CS) on rat renal cortical mitochondria was investigated. CS (30 mg .cntdot. kg-1 .cntdot. day-1) given orally to rats for 30 days caused an augmentation of renal mitochondrial oxidative phosphorylation. The ADP-stimulated respiratory rate was increased by 37.0% with glutamate plus malate as respiratory substrates (P < 0.025) but not with succinate-supported respiration, indicating enhancement of mitochondrial complex I activity. This reaction may be a response to the 32.5% reduction of renal blood (P < 0.005) in the CS-treted group, possibly serving to maximize ATP synthesis during ischemia. Ligation-induced decreases in renal blood flow also resulted in enhancement of mitochondrial complex I activity.