Post-operative intra-arterial chemotherapy in patients with malignant bone and soft tissue tumors
Yoh, S.; Arinaga, M.; Takagishi, N.; Isayama, T.; Soejima, O.; Fukabori, Y.; Yoshitake, K.; Izaki, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 16(8 Part 2): 2718-2721
1989
ISSN/ISBN: 0385-0684 PMID: 2782883 Document Number: 342487
Fourteen patients with bone and soft tissue sarcoma were treated with post-operative intra-arterial chemotherapy. Three drugs (Adriamycin, vincristine, carboquone or THP-adriamycin, cisplatin, vindesine) or two drugs (cisplatin, vindesine) were used post-operatively for patients with local recurrence, patients with poor response of pre-operative intra-arterial chemotherapy or patients with intra-lesional or marginal surgical margin. Of the 14 patients treated with post-operative intra-arterial chemotherapy, 8 (57.1%) were continuously disease-free (7.1%) were disease-free after treatment of lung metastasis, 2 (14.3%) had a local recurrence and/or multiple distant metastasis, and 3 (21.4%) died with multiple distant metastases. The rate of local recurrence was 14.3%. The Kaplar-Meier disease free survival curves showed 59.6%). Evaluation of limb function were excellent or good in 9 (69.2%) of 13 patients treated with limb-saving procedures.