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3H]-acetylcholine release from rat atria in chronic chagasic cardiopathy

Figuerêdo-Silva, J.; Coutinho-Netto, J.; Bestetti, R.B.; Oliveira, J.S.

Brazilian Journal of Medical and Biological Research 22(6): 737-740

1989

ISSN/ISBN: 0100-879X
PMID: 2695196
Document Number: 342296
Isolated superfused rat atria release [3H]-acetylcholine when depolarized with 57 mM potassium. The depolarization-induced [3H]-acetylcholine overflow was significantly reduced in atria from chronically T. cruzi-infected rats with electrocardiographically characterized cardiopathy. This fact suggests the occurrence of functional alterations of cardiac parasympathetic control in these animals, probably related to cardiac ganglion cell destruction.

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