Comparison of the methods of in vitro evaluation of the neutralizing properties of drugs from the antacid group
Pawlaczyk, J.; Kokot, Z.; Urbowicz, G.; Ewertowska, D.
Acta Poloniae Pharmaceutica 46(3): 272-279
1989
ISSN/ISBN: 0001-6837 PMID: 2618772 Document Number: 341744
Usefulness of the pH-stat method for assaying the neutralizing activity of antacids was compared with the ones of the methods based on the determination of the action time by dynamic methods. A high level of correlation between the antacid dose and the neutralization capacity has been stated. The found relationships proved to enable optimization of the antacid dosage as well as prediction of the therapeutic effect.
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