Specific and non-specific contrast media for MRi of tumors. Experimental study of human breast carcinoma
Revel, D.; Ogan, M.; Paajanen, H.; Grodd, W.; Couet, W.; Rosenau, W.; Brasch, R.C.
Journal de Radiologie 70(2): 115-121
1989
ISSN/ISBN: 0221-0363 PMID: 2715972 Document Number: 341651
MRI has been shown as an adapted non-invasive modality for the detection of tumours in humans. The development of paramagnetic contrast agents could add to the MRI diagnosis. With an experimental model of human breast (MX-1) carcinoma developed in nude mice, two different classes of contrast medium were tested. The first class includes the well-known Gd-DTPA and a new nitroxide compound on going development, representing non specific contrast agents. The specific contrast agents are represented by a metalloporphyrin Mn-TPPS4. Non specific contrast agents can add to the differentiation between well vascularized viable tissue and necrotic areas of tumors. While specific contrast agents may specifically target tumorous tissue.