Mechanism of psychotropic effect of toluene
Sklenovský, A.; Navrátil, J.; Chmela, Z.; Rypka, M.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae 121: 261-266
1989
ISSN/ISBN: 0301-2514 PMID: 2533805 Document Number: 340833
An acute 30 min exposure to toluene vapours (0.32 mmol/l of the air) provoked in the rat brain a decrease of total nonesterified fatty acids (arachidonic acid -21.7%, oleic acid -18.3%, stearic acid -7.9% in the brain cortex and arachidonic acid -6.8% in the hypothalamus). The results are in harmony with the hypothesis of the NEFA decreasing effect of the inhibitory substances in the brain.