Antiblastic treatment of advanced cervical carcinoma and its recurrences: assessment of four different polychemotherapies used for a decade
Rigano, A.; Adamo, V.; Altavilla, G.; d'Aquino, S.
European Journal of Gynaecological Oncology 10(4): 271-276
1989
ISSN/ISBN: 0392-2936 PMID: 2476314 Document Number: 340342
Eighty-seven women with advanced cervical carcinoma were treated, in 10 years, with systemic antiblastic chemotherapy using 4 different regimens in 4 successive periods: first VBM, then MAB, CDDP and finally BMFt. Selection of a regimen different than the initial one aimed to obtain a better response and less toxicity. As a whole, 25% positive responses (CR and PR) and an SD which varied from 31.4% to 58.3% were obtained. Among the regimens used, the one with bleomycin, methotrexate and ftorafur had a response rate (OR + SD) of 75% which is higher than what was obtained with regimens VBM and MAB and is similar to CDDP. Less toxicity with greater compliance were shown.