The role of obesity, hypertension and diet in diabetes and its complications in the Spontaneous Hypertensive/NIH-corpulent rat
Michaelis, O.E.; Carswell, N.; Velasquez, M.T.; Hansen, C.T.
Nutrition 5(1): 56-59
1989
ISSN/ISBN: 0899-9007 PMID: 2520260 Document Number: 340194
The Spontaneous Hypertensive/NIH-corpulent rat is a recently developed genetic model of obesity and diabetes. The strain exhibits both metabolic and histopathological characteristics associated with non-insulin dependent diabetes mellitus in humans. This rodent model is unique in that glucose intolerance is expressed in both sexes and in both phenotypes.
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