EEG changes and symptomatic parkinsonism after intracaudate administration of dopamine antibodies
Kryzhanovskiĭ, G.N.; Atadzhanov, M.A.; Magaeva, S.V.; Basharova, L.A.; Vetrilé, L.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 107(1): 13-16
1989
ISSN/ISBN: 0365-9615 PMID: 2914165 Document Number: 339857
Intracaudate bilateral injection of the dopamine antibodies caused the formation of the generator of pathologically enhanced excitation in caudate nuclei. All the rats exhibited the oligokinesia, rigidity and head tremor were observed in most animals. These abnormalities could be observed during 24 hours. The possible role of dopamine antibodies in parkinsonism pathogenesis is discussed.