Antipsychotic Induced Symptomatic Hyperprolactinemia: Are Dopamine Agonists Safe?
Lertxundi, U.; Domingo-Echaburu, S.; Peral, J.; García, M.
Psychopharmacology Bulletin 44(3): 66-68
2011
ISSN/ISBN: 0048-5764 PMID: 27738363 Document Number: 654465
Published literature shows that dopamine agonists can reverse antipsychotic-induced hyperprolactinemia without worsening psychotic symptoms in the majority of schizophrenic patients. However, psychiatrists have been reluctant to use drugs with dopaminergic properties for fear of exacerbating psychiatric symptoms. There are reported cases of psychosis worsening published for both cabergoline and bromocriptine. Cabergoline has proven to be more effective and safe when used to treat hyperprolactinemia, but whether cabergoline is also safer than bromocriptine in antipsychotic induced hyperprolactinemia remains unproven.