Immunosuppresive effects of wilfortrine and euonine
Zheng, Y.L.; Xu, Y.; Lin, J.F.
Yao Xue Xue Bao 24(8): 568-572
1989
ISSN/ISBN: 0513-4870 PMID: 2618700 Document Number: 339843
Wifortrine and Euonine isolated from Tripterygium wilfordii Hook. f. Wilfortrine and euonine (40,80 mg/(kg.d) .times. 4d ip) showed marked depressant effects on humoral immunity using the hemolysin reaction as indices. Wilfortrine (160 mg/kg.d .times. 9d ip) exhibited a depressant effect on graft vs host reaction (GVHR), but wilfortrine (80 mg/(kg.d) .times. 9d ip) showed no definite effect. euonine (80 mg/(kg.d) .times. 10d ip) showed marked suppressant effects on DNCB induced delayed hypersensitivity reaction on skin in mice. Wilfortrine and Euonine (80 mg/(kg.d) .times. 4d ip) significantly decreased the clearance of charcoal particles and the weights of spleen and thymus.