Study of the tissue localization of carcinoembryonic antigen in tumors of the colonic mucosa
Markova, E.; Kamenova, M.
Eksperimentalna Meditsina i Morfologiia 28(4): 12-16
1989
ISSN/ISBN: 0367-0643 PMID: 2627895 Document Number: 339798
The results from a immunohistochemical study on monoclonal CEA in 21 colorectal tumours and in 2 adenomas with various degree of dysplasia are described. CEA becomes positive slightly with predominance of its membranous localization in adenomas without dysplasia and with dysplasia of I degree. CEA is manifested by more intensive reaction and although rarely it is found diffusely in the cytoplasm in dysplasia of II degree. CEA is found in a large part of tumourous cells and is mainly of cytoplasmic type in dysplasia of III degree. In all examined carcinomas there is positive reaction of CEA, which is distinguished with intensity and larger distribution. In 50% of patients with carcinoma CEA is found also in stromal cells, which is interpreted as a manifestation of invasive properties of the tumours. The authors find positive correlation between the degree of dysplasia and the type of distribution of CEA. In conclusion the significance of tissue discovery of CEA in adenomas of the rectum as an additional method for determination of the exact degree of dysplasia is emphasized.