Fatal toxic epidermolysis following administration of allopurinol
Coutellier, P.; Delgrange, B.
Acta Clinica Belgica 44(3): 196-198
1989
ISSN/ISBN: 1784-3286 PMID: 2816227 Document Number: 339565
Six days after initiating therapy with allopurinol, toxic epidermal necrolysis developed in a 73-year-old man with renal failure. It was responsible for a generalized vasculitis and gastrointestinal bleeding ultimately leading to death. The authors emphasize the need for a careful evaluation before prescribing this medication, particularly in patients with renal failure.
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