Importance of endogenous opioids and prostaglandins in the action of analgin (metamizole) and verapamil
Vlaskovska, M.; Surcheva, S.; Ovcharov, R.
Farmakologiia i Toksikologiia 52(3): 25-29
1989
ISSN/ISBN: 0014-8318 PMID: 2507348 Document Number: 339349
The effects of a non-narcotic analgetic methamizole and the calcium channel blocker verapamil on carrageenan hyperalgesia, release of beta-endorphin and synthesis of prostaglandin E2 (PGE2) were studied. It was found that a combined administration of analgin and verapamil prolonged the analgesic effect. Analgin stimulated release of beta-endorphin with the maximum coinciding in time with the peak of the analgesic effect. Against the background of the action of calcium ionophore A 23187 the combination of analgin with verapamil inhibited PGE2 synthesis more distinctly. The combination of these pharmacological agents is suggested to exert the effect both at different levels, central and peripheral, and on various cellular mechanisms involved in pain modulation.