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The reaction of the endocrine cells of the gastrointestinal tract in response to exposure to 3,6-dichloropicolinic acid

Iaglov, V.V.; Ptashekas, I.R.

Biulleten' Eksperimental'noi Biologii i Meditsiny 107(6): 758-761

1989

ISSN/ISBN: 0365-9615
PMID: 2790179
Document Number: 339129
Silver-impregnated argentaffin cells both Ec, D1, G, P, S and K enteroendocrine cell types of rat gastrointestinal mucosa were investigated under light and electron microscopy after single oral administration of 3,6-dichloropicolinic acid. As a result, in pyloric-duodenal region Ec cells after a period of 1 hour had intensively secreted hormones. Ultrastructurally their cytoplasm and secretory granules were covered by expressed vacuolization. These data hypothetically elucidate the role of the endocrine regulations in developing barrier function of the gastrointestinal epithelium.

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