Side effects in chemoradiotherapy of bladder cancer
Shipilov, V.I.; Gorbunova, V.A.; Barkanov, A.I.
Voprosy Onkologii 35(1): 76-80
1989
ISSN/ISBN: 0507-3758 PMID: 2919507 Document Number: 338765
Chemoradiation treatment was given to 60 patients with locally-advanced cancers of the urinary bladder and their recurrences. Split-course radiotherapy was carried out using a rotation technique at 3-4 week intervals. Total focal dose for two courses was 65-70 Gy. Combined therapy used cyclophosphamide, dactinomycin and cisplatin. Chemotherapy was given immediately after each course of irradiation. Concomitant cardiovascular pathology was registered in 46.6% of patients and renal function derangement--in 36.6%. However, all the patients, except three, received treatment matched by symptomatic therapy. Myelosuppression was among major side effects. Response was assessed in 47 cases (75%). The immediate effect of combined treatment was observed in 57.4%.