Differential diagnosis of osteomalacia and other forms of renal osteodystrophy in terminal renal failure by dynamic scintigraphy with diphosphonate
Novikov, A.I.; Ermolenko, A.E.; Ermakova, I.P.; Baeva, L.B.; Levitskiĭ, E.R.
Terapevticheskii Arkhiv 61(6): 105-109
1989
ISSN/ISBN: 0040-3660 PMID: 2799693 Document Number: 338614
During osteomalacia in patients with terminal renal failure, the coefficient of diphosphonate elimination from the blood bed (K1) was less than 0.1 min-1, which was determined by the rise of the concentration of uremic toxins, inhibiting interaction of the radiopharmaceutical with the bone, in the patients' tissues. Dynamic scintigraphy permits one to study the pharmacokinetics of diphosphonate in every patient and thus can be used for differential diagnosis between osteomalacia and other forms of renal osteodystrophy.