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Adoptive immunotherapy of tumor in mice in combination with cyclophosphamide

Sarna, S.; Bhola, R.K.

Archivum Immunologiae et Therapiae Experimentalis 37(5-6): 533-538

1989

ISSN/ISBN: 0004-069X
PMID: 2487364
Document Number: 337602
Cyclophosphamide causes temporary regression of Dalton's lymphoma when injected at palpable stage. Dose-dependent response to cyclophophamide was analyzed. Low dose was found to be most effective as compared to the high dose. Adoptive transfer of immunized splenocytes after cyclophosphamide therapy protects the animals from the danger of reappearance of tumor. Such combination therapy is proved to be effective in causing complete and permanent regression of tumor in majority of the treated animals.

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