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Epidemic hemorrhagic fever with renal syndrome in Yugoslavia, 1986

Gligić, A.; Obradović, M.; Stojanović, R.; Vujosević, N.; Ovcarić, A.; Frusic, M.; Gibbs, C.J.; Calisher, C.H.; Gajdusek, D.C.

American Journal of Tropical Medicine and Hygiene 41(1): 102-108

1989

ISSN/ISBN: 0002-9637
PMID: 2569845
Document Number: 337483
An epidemic of hemorrhagic fever with renal syndrome (HFRS) occurred in Yugoslavia May-November 1986; all Republics and Provinces were involved. Serum samples were received from 260 of 276 persons with symptoms clinically compatible with a diagnosis of HFRS. Presumptive infection with a hantavirus was determined serologically for 161 of these. Many patients with serious clinical pictures, including severe renal insufficiency and shock, were hospitalized; 11 died. Indirect fluorescent antibody tests with antigens of 4 hantaviruses (Hantaan, Fojnica, Puumala, and the Vranica strain of Puumala virus) showed that greater than 1 serotype was circulating during this epidemic. Hantavirus antigens were detected in the lungs of 86 of 302 (28.5%) wild-caught small mammals.

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