A study on the distribution of T-3262 (tosufloxacin tosilate) in salivary glands of rats using microautoradiography
Morihana, T.; Sakai, H.; Hayakawa, H.
Japanese Journal of Antibiotics 42(9): 1868-1872
1989
ISSN/ISBN: 0368-2781 PMID: 2810749 Document Number: 337339
The distribution of T-3262 (tosulfoxacin tosilate) in salivary glands of rats was investigated frozen-microautoradiography. One and 4 hours after oral administration of 14C-T-3262 at 100 mg/kg to rats submandibular glands, parotid glands and sublingual glands were removed, and a microautoradiogram of each was made. In the submandibular gland and the parotid gland 14C-T-3262 was distributed at high levels throughout the glands taken at 1 and 4 hours after administration, but lower levels than the other glands were found in the sublingual gland at 1 hours. The results of this study suggested that T-3262 penetrates effectively into the saliva, because 14C-T-3262 is distributed well into glandular acinus, striated duct and excretory duct. The microautoradiography was a useful and reliable method for investigating the distribution of antimicrobial agents in salivary glands.