Distribution of hepatitis B virus in a Center for the Psychologically Handicapped in Madrid. Risk indicators
Jover Ibarra, J.; Ramírez Marín, V.
Revista de Sanidad E Higiene Publica 63(1-2): 111-118
1989
ISSN/ISBN: 0034-8899 PMID: 2636783 Document Number: 337290
A total of 252 institutionalized mentally retarded patients were studied in a Centre in Madrid, to Know the distribution of HBV in this populations. 74 clients with Down's Syndrome (DS) and 178 were retarded due to other etiologies (NDS): congenital rubella, perinatal influences, encephalitis, etc.. Also we studied the distribution of HBV among the health workers of the Centre (N = 100). We investigate in all the subjects (patients and employees) three variables: 1) patients with any marker of HBV present, 2) carriers of HBV, and 3) their infectivity (HBeAg+). To know an estimate of risk of HBV we design a matched case-control study and we controlled the confounding factors as age, sex, duration of institutional stay and contacts with HBV before institutionalization. Before matching, the crude data were: Patients with any marker of HBV were 123 (49%); employees: 17 (17%). Clients with HBsAg: 35 (14%); and health workers 1(1%). Antigen HBe+ in clients 22(62%) and nobody among the employees. We compare the group of patients with DS and the others inmates and we obtained: Any marker among DS's 51 (69%) and 72 (40%) in the group of NDS's. They were 22 (30%) carriers among DS patients and 13 (7.30%) in the other clients. It was HBeAg present in 18 (82%) in DS's and 4 (30%) in patients with NDS. The case control matched study allowed to know an estimate of risk (OR) of HB comparing the two groups. Thus, the OR for the first variable was: OR = 2.5, p = 0.037, CI (OR, OR) 95% = (1.054, 5.91).