Effect of dietary K+ and 75% nephrectomy on the morphology of principal cells in CCDs

Zalups, R.K.

American Journal of Physiology 256(3 Pt 2): F387-F396

1989


ISSN/ISBN: 0002-9513
PMID: 2923219
Document Number: 337214
Rats that had 75% of their kidneys removed (NPX) and were given a diet deficient in potassium for 10 days after surgery had a lower concentration of K in blood and excreted less K in urine than corresponding sham-operated (SHO) rats or NPX rats given a diet normal in K. In the NPX rats given the diet deficient in K, there was a marked inhibitory effect on the amplification of the basolateral membrane, which normally occurs in main cells of cortical collecting ducts after renal mass has been greatly reduced. In fact the surface density of the basolateral membrane, as well as the size of the main cells in the rats given the diet deficient in K were the same as those of main cells in the SHO rats given the diet normal in K.

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