Granular cell tumor of the stomach coincident with two early gastric carcinomas
Yamaguchi, K.; Maeda, S.; Kitamura, K.
American Journal of Gastroenterology 84(6): 656-659
1989
ISSN/ISBN: 0002-9270 PMID: 2543214 Document Number: 336497
In a 64-yr-old Japanese man, granular cell tumor of the stomach plus two early gastric carcinomas were detected. The granular cell tumor was a 1.5 x 1.5-cm submucosal nodule located in the posterior wall of the fundus. The mucosa adjacent to the granular cell tumor showed two well-differentiated adenocarcinomas restricted to the mucosa, but there was no continuity among these three conditions. This seems to be the first report of this type of association. Immunohistochemical study revealed S-100 protein in the component cells of the granular cell tumor, thereby supporting the proposal that this granular cell is derived from Schwann cells.