Metabolic diversions in the oxidative metabolism of hepatic and neuronal systems of rat (Wistar strain) under induced benthiocarb stress
Babu, G.R.; Reddy, G.R.; Srinivas, P.N.; Chetty, C.S.
Biochemistry International 19(3): 477-487
1989
ISSN/ISBN: 0158-5231 PMID: 2818608 Document Number: 335306
Metabolic diversions in oxidative metabolism of hepatic and neuronal systems of rat were noticed during induced benthiocarb stress. The inhibition of dehydrogenases indicates disturbed mitochondrial integrity, and reduction in cytochrome-C-oxidase suggests possible respiratory distress. The drop in ATPases and PNPPase indicates the prevalence of energy crisis. The increased specific activities of NADP+ dependent dehydrogenases suggests augmented lipid biosynthesis in the wake of impaired oxidative metabolism.