Mechanisms of thrombin-induced plasminogen activator release
Klöcking, H.P.; Hoffmann, A.
Folia Haematologica 116(6): 895-899
1989
ISSN/ISBN: 0323-4347 PMID: 2483708 Document Number: 334906
The protein kinase C inhibitor H7 (10(-5) mol/l) is able to inhibit the thrombin-induced t-PA release in the isolated perfused pig ear. The thrombin-induced t-PA release can be blocked by increasing the intracellular c-AMP via either the activation of adenylate cyclase by means of forskolin, or the inhibition of the phosphodiesterase by means of motapizone or milrinone. Protein kinase C is assumed to be involved in the process of thrombin-induced t-PA release.
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