Scintigraphic quantitation of splenic function in SLE: correlation with IgM levels in serum
Wilson, W.A.; Perez, M.C.; Marwah, R.; Foreman, J.B.; McGrath, H.
Clinical and Experimental Rheumatology 7(3): 251-255
1989
ISSN/ISBN: 0392-856X PMID: 2758705 Document Number: 334426
The relationship between quantitative splenic uptake of sulfur colloid and immunoglobulin M level in serum was studied in 15 patients with systemic lupus erythematosus (SLE). Splenic function correlated positively with IgM level (r = 0.58, p = 0.02) and inversely with antibody titre to n-DNA (r = -0.74, p = 0.003), and was reduced (p greater than 0.001) in patients with depressed IgM levels. IgM level in serum may be a useful correlate of splenic phagocytic function in SLE patients.