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Chrysotile A affects YAC-1 cytolytic activity of spleen cells

Moniewska, A.; Szyba, K.; Jaźwiec, B.; Lange, A.

Archivum Immunologiae et Therapiae Experimentalis 37(1-2): 61-68

1989

ISSN/ISBN: 0004-069X
PMID: 2559675
Document Number: 333447
Effect of short exposure of C57Bl/6 and F1/NZB x C57Bl/6/ mice to i.p. injected chrysotile A on YAC-1 cytolytic potential (NK cell function) of spleen cells was investigated. It was found that 3 days after injection, cytolytic activity of spleen cells was significantly abrogated and this was paralleled with an increase of alpha-naphtyl acetate esterase positive cells/macrophages in spleen cell population. In addition, effect of exposure of mice to i.p. injected chrysotile A coated with benzo(a)pyrene (BaP) was investigated. BaP did not modify the abrogative effect of chrysotile A on NK cell function. Asbestos fibres themselves were sufficient for depletion of NK cell function of spleen cells.

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