Mechanism of action of aldosterone as a regulatory factor of the extracellular volume
Crabbe, K.
Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 144(1-2) 176-186; Discussion: 186-187
1989
ISSN/ISBN: 0377-8231 PMID: 2804478 Document Number: 333416
Aldosterone as a regulatory factor of extracellular volumes: mechanism of action. The key role assumed by aldosterone in the regulation of extracellular volumes, requires that chloride move along with sodium when active transport of the latter ion is stimulated. In the mammalian nephron, aldosterone promotes reabsorption of sodium by the principal cells of the cortical portion of the collecting duct. This results from hormone-induced increase in conductance for sodium at the apical role of the target cells, and later on, from associated increased density of the sodium "pump" units at the basolateral pole. Studies carried out on amphibian epithelia indicate that chloride permeability-of mitochondria-rich cells, and in all likelihood--is concurrently increased by aldosterone. It therefore looks as though this steroid hormone influences in a concerted way two cell populations, one being involved in transepithelial sodium transport, the other one representing the route of passage for the accompanying anion.