Studies on CFU-Mix in 54 cases of leukemia and myelodysplastic syndrome
Chen, Y.; Wang, B.M.; Li, C.Y.
Zhonghua Nei Ke Za Zhi 28(1): 35-38; 62-63
1989
ISSN/ISBN: 0578-1426 PMID: 2737036 Document Number: 332773
By use of limiting dilution assay, it is confirmed that most of acute nonlymphocytic leukemia, such as chronic myelogenous leukemia and myelodysplastic syndrome, had defect in the stage of pluripotent hemopoietic stem cell. With light microscopy, scanning and transmission electron microscopy, colonies which originated from leukemic progenitor cells (L-CFU) were ascertained. The incorporated rates of 3H-TdR and 55 + 59Fe showed that proliferative manner of LCFU was apparently different from that of normal adults.