Effects of forskolin on the longitudinal internal resistance (ri) in rabbit sinus node strips
Tuganowski, W.; Korczyńska, I.; Wasik, K.; Wójcik, B.; Bukowski, M.
Acta Physiologica Polonica 40(2): 164-170
1989
ISSN/ISBN: 0044-6033 PMID: 2561891 Document Number: 332399
The effect of several concentrations of 7-0-hemisuccinyl, 7-deacetyl forskolin on ri was studied by means of microelectrode and single sucrose gap techniques. Twenty .mu.mol .cntdot. l-1 of forskolin added to those sucrose gap lowered ri by 15% below the control value. The drug applied at 50 .mu.mol .cntdot. l-1 initially decreased ri by 31%, and then it increased the resistance by 43% above the control value. The possible mechanisms underlying these effects are discussed in terms of cAMP and Ca action on the cell coupling.