Magnesium monoperoxophtalate: an efficient single oxygen atom donor in DNA cleavage catalyzed by metalloporphyrin
Pratviel, G.; Bernadou, J.; Ricci, M.; Meunier, B.
Biochemical and Biophysical Research Communications 160(3): 1212-1218
1989
ISSN/ISBN: 0006-291X PMID: 2525035 Document Number: 332328
The peracid compound magnesium monoperoxophtalate (MMPP), water-soluble at physiological pH, behaves as a promising oxygen donor in the oxidative cleavage of DNA catalyzed by meso-tetrakis-(4-N-methylpyridyl)porphyrinatomanganese (III) pentaacetate. Shown on cleavage of supercoiled .PHI. X174 DNA, MMPP is significantly more efficient than KHSO5, another recently developed single oxygen atom donor (Fouquet et al., J. Chem. Soc., Chem. Commun., 1987, 1169).