The effect of metoclopramide on the hypophyseo-ovarian relations in patients with amenorrhea resulting from body mass loss
Potin, V.V.; Isakov, A.V.; Svechnikova, F.A.
Problemy Endokrinologii 35(2): 44-48
1989
ISSN/ISBN: 0375-9660 PMID: 2500651 Document Number: 331487
The levels of FSN, LH, prolactin, estradiol, and progesterone were investigated in the blood of 26 women with hypothalamic amenorrhea (in 17 of them it resulted from body mass deficiency) before and during metoclopramide therapy (the drug was administered at a daily dose of 20 mg for 1 = 9 mos). The administration of the drug per os in 3 h resulted in a considerable rise of the blood level of prolactin in patients with body mass deficiency. Regular administration of the drug in this group normalized the anovulatory cycle in 5 women and caused pregnancy in one woman. In the authors opinion, this effect was due to a decrease in dopaminergic inhibition of the anterior pituitary lobe and the restoration of the mechanism of positive feedback between the ovaries and pituitary gland.