Streptococcus group B tardive meningitis revealing chronic septic granulomatosis
Garel, D.; Devictor, D.; Tchernia, G.; Pham, T.; Dommergues, J.P.
Annales de Pediatrie 36(1): 35-37
1989
ISSN/ISBN: 0066-2097 PMID: 2648937 Document Number: 331335
A first-born boy operated on D20 for an abscess of the anal margin (E. Coli, Klebsiella) developed purulent meningitis due to a group B serotype III streptococcus on D35. The outcome was rapidly fatal. Results of immunologic investigations done on the day before death were suggestive of chronic granulomatous disease (CGD) as complete absence of reduction of nitroblue tetrazolium (NBT) was evidenced. Studies of polymorphonuclear cells from the mother showed normal production of oxygen, chemiluminescence and NBT reduction. During the subsequent pregnancy, fetal blood was sampled 19 weeks after the last menstrual period; results showed the fetus was male and the polymorphonuclear cells were incapable of reducing NBT and exhibited decreased chemiluminescence and oxygen production. The pregnancy was terminated. This case shows that delayed group B streptococcus infection can occur as the first manifestation of CGD, although this condition is usually responsible for infections due to staphylococci, enterobacteriaceae and yeasts.