Nutritive utilization of phosphorus in the rat: influence of intestinal resection and dietary medium chain triglycerides and vitamin D3
Barrionuevo, M.; Campos, M.S.; López Aliaga, I.; Coves, F.; Lisbona, F.
International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 59(3): 255-261
1989
ISSN/ISBN: 0300-9831 PMID: 2557293 Document Number: 331109
The effects of intestinal resection and diet on the digestive and metabolic utilization of phosphorus were studied in adult rats from which 50% of the distal small intestine had been removed and in sham-operated controls. Metabolic parameters were measured both 1 and 3 months after surgery. The loss of half of the distal small intestine led to a decline in digestive utilization of phosphorus 1 month after surgery as reflected in bone mineral content. Digestive efficiency had improved by 3 months after surgery. One month's feeding with a diet in which fat was provided as equal parts of medium chain triglycerides, sunflower seed oil and olive oil instead of 100% olive oil enhanced phosphorus absorption and retention, although this improvement was less evident after 3 months. The negative effects of distal small intestine resection on the nutritive utilization of phosphorus were not only palliated but significantly enhanced by supplementing the diet with vitamin D3 at a rate of 0.08 mg/100 g diet. This dose is within physiological limits, and favors phosphorus deposition in bone tissue.