Various characteristics of collagen metabolism in patients with chronic diseases of the liver
Geĭvandova, N.I.; Iagoda, A.V.; Mosin, V.I.
Klinicheskaia Meditsina 67(11): 59-62
1989
ISSN/ISBN: 0023-2149 PMID: 2625962 Document Number: 331060
The correlation of collagen metabolism to liver contents of cyclic AMP and GMP as well as blood level of hormones was investigated in 105 patients with chronic hepatitis and liver cirrhosis. In patients with active hepatitis and cirrhosis showing the highest intensity of collagen metabolism there appeared elevated levels of cyclic AMP, somatotropic hormone and insulin against low levels of hydrocortisone and thyroxin. The relations between characteristics of plasma protein-bound oxyproline (PBOP), circadian oxyprolinuria and regulatory mechanisms under study suggest a competitive control of hepatic connective tissue metabolism maintained by hormones via cyclase systems. In high levels of blood PBOP and low ones of hydrocortisone, glucocorticoids unlike D-penicillamine promoted inhibition of liver collagen synthesis.