Comparative effectiveness of Na+ channel blockers in ventricular disorders of cardiac rhythm
Orlov, V.N.; Shpektor, A.V.; Mamaev, V.I.; Susliak, N.N.
Kardiologiia 29(8): 45-50
1989
ISSN/ISBN: 0022-9040 PMID: 2479795 Document Number: 330824
The effectiveness of ethacizine, neo-gilurytmal, disopyramide, ethmozine, novocainamide, and mexitil was compared in 97 patients with ventricular cardiac rhythm distrubances. The effect of the drugs was evaluated by 24-hour long ECG monitoring. Clinical and ECG parameters were compared in patients who were sensitive or resistant to the effect of antiarrhythmic preparations. Some complications of the antiarrhythmic therapy were described. The results of the study show that all Na-channel blockers being used stop arrhythmias caused by reentry or trigger activity more effectively, than arrhythmias caused by automatism disturbances.