Update on nitroglycerin use
Andrien, P.; Lemberg, L.
Heart and Lung the Journal of Critical Care 18(1): 100-101
1989
ISSN/ISBN: 0147-9563 PMID: 2492267 Document Number: 330726
Tolerance to nitrates occurs when this class of drugs is administered in a continuous around-the-clock regimen. Nitrate-free intervals from 10 to 12 hours are recommended to prevent nitrate tolerance. Full response with renewed administration occurs with interrupted nitrate therapy.
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