Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets
Kajikawa, N.; Nogimori, K.; Murata, T.; Nishio, S.; Uchiyama, S.
Arzneimittel-Forschung 39(4): 495-499
1989
ISSN/ISBN: 0004-4172 PMID: 2665758 Document Number: 330658
Binding of beraprost sodium (sodium dl-4--TRK-100 from the binding sites on rat platelets. PGE2, PGD2, PGF2 alpha, and pinane thromboxane A2, a stable thromboxane A2 analogoue, had no affinity for the binding sites. The relative affinity of the four enantiomers of TRK-100--APS-314d, 315d, 3141 and 3151--for the binding sites was 100: 14: less than 1: less than 1, respectively. These results suggest that TRK-100 is a useful tool for studying biological roles of PGI2 as well as for use as an antithrombotic agent since TRK-100 mimics its actions via specific interaction with PGI2 receptors.