Blood transfusions and the development of cytotoxic antibodies in dialyzed patients
Matej, H.; Kałamarz, M.; Nowakowska, B.; Pacyńska, J.; Myc, A.
Archivum Immunologiae et Therapiae Experimentalis 37(1-2): 115-120
1989
ISSN/ISBN: 0004-069X PMID: 2619495 Document Number: 330427
In our work we investigated factors which can influence the alloimmunization and especially the ranges of cytotoxic antibodies that develop in patients on dialysis awaiting their first graft. Up to 15 liters of administered blood the proportion of immunized patients is rather stabile, not exceeding 50%. After further transfustions the percentage of immunized patients is growing rapidly reaching about 85%. Hyperimmunization, marked by cytotoxic antibodies with more than 80% panel reactivity is significantly more frequent in patients who obtained 15 and more liters of blood. In females the hyperimmunization is about 4 times more frequent than in males.