Probenecid affects liver metabolism
Bammel, A.; Mönig, H.; Zurborn, K.H.; Ohnhaus, E.E.; Kirch, W.
Schweizerische Medizinische Wochenschrift 119(50): 1831-1834
1989
ISSN/ISBN: 0036-7672 PMID: 2609138 Document Number: 330285
The effect of probenecid on the pharmacokinetics of phenprocoumon (PPC) given as a single oral or intravenous dose, on the vitamin-K-dependent protein-C-antigen, and on the pharmacokinetics of antipyrine and 6.beta.-hydroxycortisol was determined in 14 healthy volunteers. Probenecid caused a 75% decrease in urinary excretion of PPC and PPC-glucuronide and shortened the plasma half-life of PPC significantly (by about 35%). The results after oral and intravenous administration of PPC did not differ significantly. Plasma protein-C-antigen concentrations following intravenous PPC were significantly increased by probenecid. The plasma half-life of antipyrine after 7 days of probenecid therapy was significantly diminished. Accordingly, urinary excretion of 6.beta.-hydroxycortisol was significantly increased. These data appear for the first time to reveal enzyme-inducing properites of probenecid, which may be responsible for the shortening of PPC plasma half-life when probenecid is given simultaneously. In addition, the influence of probenecid on plasma protein-C-antigen concentrations may indicate further effects of probenecid on liver metabolism.