Cystic fibrosis: II. Altered microviscosity of erythrocyte membrane
Witas, H.; Bartosz, G.; Bryszewska, M.; Gwoździński, K.; Gondko, R.
Cytobios 57(228): 55-59
1989
ISSN/ISBN: 0011-4529 PMID: 2731444 Document Number: 329798
Erythrocyte membrane fluidity alterations in cystic fibrosis are described. The relative flexibility of the membrane was studied using lipid spin label, i.e. methyl-5-doxylpalmitate (M5DP), and pyrene as a fluorescence probe. It was found that there was a decrease of membrane fluidity in the hydrophobic midzone of the membrane, probed by pyrene, as well as at the hydrophilic surface region, probed by M5DP.