Effect of pentosan polysulphate on endothelial regeneration
Herbert, J.M.; Floutard, D.; Paul, R.; Maffrand, J.P.
Pathologie-Biologie 37(7): 847-850
1989
ISSN/ISBN: 0369-8114 PMID: 2483584 Document Number: 329668
Endothelium was removed from rabbit aortae using a balloon catheter and the endothelial outgrowth was measured. In the controls, after initial regrowth of approximately 4 weeks, endothelial regeneration stopped before cellular regrowth was complete. However, when treated with daily subcutaneous injections of pentosan polysulphate (PPS) (8 mg/kg/day), endothelium fully repopulated the denuded areas 16 weeks after beginning of the treatment. These results illustrate the possbility of using pentosan polysulphate in the prevention of athero-genesis, by enhancing endothelial regeneration.