Synthesis of thiazole derivatives with positive inotropic effect
Kosáry, J.; Kasztreiner, E.; Rablóczky, G.; Vitális, B.
Die Pharmazie 42(6): 373-375
1987
ISSN/ISBN: 0031-7144 PMID: 3671455 Document Number: 3293
Thiazole derivatives with potential positive inotropic effect were synthesized. The highest activity (medium positive inotropic effect) was exhibited by ethyl 2-(2-hydroxyethylamino)-4-phenylthiazole-5-carboxylate (3b) of which several derivatives have been prepared. Among these derivatives only those which could presumably easily removed in the living organism to give 3b exhibited a medium positive inotropic effect (6, 8b). It was assumed that the effect of 3b had a beta-agonist character.
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