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Erdosteine protection from cigarette smoke-induced loss of alpha 1-antitrypsin activity in rat lungs

Biagi, G.L.; Fregnan, G.B.; Gazzani, G.; Vandoni, G.

International Journal of Clinical Pharmacology Therapy and Toxicology 27(5): 235-237

1989

ISSN/ISBN: 0174-4879
PMID: 2786855
Document Number: 328443
Acute inhalation of cigarette smoke induced alpha 1-antitrypsin inactivation in rat lungs. The elastase inhibitory capacity of the protein could be prevented by oral treatment with erdosteine (a mucoregulator endowed with free radical scavenging properties). A partial dose-dependent protection was observed with 500 and 1,000 mg/kg. The mechanism of its action might be related either to the inhibition of alpha 1-antitrypsin oxidation manifested by two SH groups liberated in vivo or to the anti-inflammatory and mucoregulator properties present in the substance.

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