A study of ivermectin in the treatment of lymphatic filariasis due to Wuchereria bancrofti var. pacifica in French Polynesia
Roux, J.; Perolat, P.; Cartel, J.L.; Boutin, J.P.; Sechan, Y.; Larivière, M.; Aziz, M.A.
Bulletin de la Societe de Pathologie Exotique et de Ses Filiales 82(1): 72-81
1989
ISSN/ISBN: 0037-9085 PMID: 2743520 Document Number: 328232
Forty carriers of 20 or more W. bancrofti var. pacifica per ml were blind administered ivermectin at 50, 100, 150 or 200 mcg/kg doses. The rate of successful treatment was 100% with the 4 dosages. The percentage cure rate and the decrease percentage in the microfilarial count were significantly higher in persons treated with 100, 150 and 200 mcg/kg than in persons treated with 50 mcg/kg. Frequency and intensity of side-reactions were similar to those observed during treatment with DEC; they were more frequent and severe in persons with greatest microfilaremia but did not depend on the dosage. Ivermectin in 100 mcg/kg single-dose, administered once a year, is the best candidate to replace DEC in mass treatments.