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Osteoclast-type giant cell tumor of the endometrium. An immunohistochemical study

Kawai, K.; Senba, M.; Tagawa, H.; Suzuki, K.; Matsuo, T.; Tsuchiyama, H.

Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 135(8): 743-749

1989

ISSN/ISBN: 0044-4030
PMID: 2694686
Document Number: 328054
We present a rare case of a 55 year old female with an osteoclast-type giant cell tumor of the endometrium associated with leiomyoma and adenomyosis. Multinucleated giant cells and mononuclear stromal cells reacted with vimentin and alpha-1-antichymotrypsin (AACT) using the immunoperoxidase method. Epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and keratin exhibited negative immunoreaction in these tumor cells. Our immunohistochemical results do not support the epithelial origin of an osteoclast-type giant cell tumor and mesenchymal derivation appeared more likely, suggesting histiocytic origin.

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