Evidence for a major additive gene in ulcerative colitis
Monsén, U.; Iselius, L.; Johansson, C.; Hellers, G.
Clinical Genetics 36(6): 411-414
1989
ISSN/ISBN: 0009-9163 PMID: 2591066 Document Number: 327942
Complex segregation analysis of 124 families with ulcerative colitis with two or more affected individuals suggests a rare additive major gene causing the disease with about 20% affected among the heterozygotes for the gene. There was no evidence for multifactorial inheritance.
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