Proliferation indices in malignant lymphomas
Crocker, J.
Clinical and Experimental Immunology 77(3): 299-308
1989
ISSN/ISBN: 0009-9104 PMID: 2680181 Document Number: 327551
In view of the importance of adjusting therapy to prognostic groups in malignant lymphomas, there have been numerous attempts over the past two decades to assess proliferation rates in these neoplasms. The techniques employed include radiolabelled thymidine uptake, DNA flow cytometry, the application of antibodies to proliferation-associated antigens and the enumeration of nucleolar organizer regions. The evolution of these methods is reviewed and their usefulness is evaluated.