Experimental studies on the role of retinal lipid peroxidation induced by intraocular iron foreign body
Lu, Z.L.
Zhonghua Yi Xue Za Zhi 69(12): 690
1989
ISSN/ISBN: 0376-2491 PMID: 2630018 Document Number: 327501
Experimental studies were made to evaluate the role of lipid peroxidation in retinal damage by intraocular iron foreign bodies. It was found that after iron particles were implanted into the vitreous bodies (1) iron concentration in the aqueous humour rose rapidly and significantly (n = 24, P less than 0.01), (2) malondialdehyde (MDA) a degradation metabolite of lipid peroxidation, in the retinas increased significantly (n = 24, P less than 0.05), and (3) superoxide dismutase (SOD) activity decreased (n = 11, P less than 0.05). These findings suggest that lipid peroxidation plays a key role in the retinal damage of siderosis bulbi, and provide a solid basis in studying the pathogenesis and guiding clinical management of the disease.